Endocrine Abstracts

Transforming growth factor β1 has a critical role in the regulation of testicular function. Transgenic male mice over expressing α and β subunits of hCG (hCG+) are infertile and testicular steroidogenesis is enhanced showing high levels of testosterone and progesterone (P4). The chronic hCG hyperstimulation leads to Leydig cell (LC) hypertrophy/hyperplasia in prepubertal mice.Aims: To analyze: i) the expression of the TGF-β...